Project

Bioinstrumentation

We are a developing an unbound, non-invasive monitoring device for local clinics, core hospitals and health centers that uses advanced optical and acoustic technology solutions for early screening of diseases.

Research Representative
Yuji Matsuura

Yuji Matsuura, Graduate School of Biomedical Engineering
Development of Optical-Fiber Catheter Transmitting Near-Infrared and Infrared Light for Endoscopic Treatment and Diagnosis

Non-invasive treatment and diagnosis systems using infrared optical fibers were developed. Two main topics discussed here are i) optical guide systems to prevent insertion failure of feeding catheter, and ii) non-invasive blood-glucose measurement using infrared fiber probe. The optical guide system is composed of near-infrared laser diode and polymer optical fibers. The distal end of catheter is exactly located by observing light transmitted through human body using a CCD camera. The light guiding probe includes three optical fibers whose output ends were cut in a slant angle to emit light in radial directions. The observation system was synchronized with blinking of light source to emphasize weak transmitted light. As a result of feasibility test with a human volunteer using this system, light transmitted from stomach was clearly observed. The measurement system of blood glucose levels is based on infrared attenuated-total-reflection spectroscopy. The system employs hollow optical fibers so that any part of human body can be measured. It also include a multi-reflection prism that enables highly sensitive measurement with high reproducibility. In measurement of human blood glucose levels, absorption spectra of inner lips were measured and to suppress effects of individual optical properties, differential spectra from the fasting stages of were calculated. In these differential spectra, clear traces of glucose in lip mucosa were observed and measurement errors of blood glucose levels were less than 20%.

Visiting Researcher
Mitsuo Kawase

Mitsuo Kawase, Graduate School of Biomedical Engineering
Development of simple and rapid genetic testing tool

In infectious diseases, the examination using DNA, for example, determination of bacterial species infected in human as well as animals or drug resistances of the infected bacteria, is considered to be one of powerful tools, because the findings obtained from the above examination help us to determine the medical treatments for the infected patients and animals. However, since the current DNA testing method requires expensive equipment and high level skills, the DNA testing is not so popularly used in medical field. The advent of the simple and less expensive DNA testing tool is being awaited for the above examination. In the present project, we have made a key technology fit for practical use, which allow us to detect a desired PCR products by adding specific tag sequences to one of primer pairs and by hybridization of tag sequences to their complementary sequences immobilized on nitrocellulose strips.

Researchers

Hiromasa Ogawa, Center for Environmental Conservation and Research Safety/Graduate School of Medicine
Development of the pressure variable controlled tidal expiratory flow monitoring device   [from FY2012]

Background: Spirometry is an essential tool for screening and diagnosis various lung conditions. In general practice, the underuse of spirometry leads to the under-diagnosis of respiratory diseases. Barriers to spirometry use include difficulty of the technique, need of patient cooperation, lack of time, and lack of knowledge for interpretation. Aim: This aim is to develop a new cooperation-free simple measuring device as a substitute for spirometer.
Method: We have developed a new device to monitor the change in tidal expiratory flow by applying variable negative pressure at the mouth during tidal expiration.
Results: The tidal expiratory flow increased by increasing the negative pressure during tidal expiration. The reduction in increment of the tidal expiratory flow occurred in obstructive ventilatory impairment. The change in increment of the tidal expiratory flow by variable negative expiratory pressure was shown to be useful for detecting ventilatory impairments
Conclusion: This result suggests that this new cooperation-free simple measuring developed device, is a substitute for spirometer. Now we are collecting patients’ data in order to establish clinical index for diagnosis of ventilatory impairments in clinical use.

Hajime Kurosawa, Center for Environmental Conservation and Research Safety/ Graduate School of Medicine
Development of tablet-interfaced system for measuring respiratory system impedance   [from FY2012]

Nariyasu Mano, Tohoku University Hospital
Development of an automatic system for mixing and preparing high function anticancer agents
[from FY2012]

We developed a high performance automatic system for mixing and preparing for anticancer injection drugs (AccuDisp○R) with Universal Giken Co.,Ltd. This machine consists of a revolving syringe, a dissolving device, and a weighing system without any robotic arms. To set it into a commercial available safety cabinet is important, and our machine firstly performed downsizing all over the world. In addition, this machine can be full automatically operated with a workstation. Therefore, it does not require any specific technique of healthcare professionals.

Development of an automatic system for mixing and preparing anticancer agents   [from FY2015]

Masahiro Hiratsuka, Graduate School of Pharmaceutical Sciences
Development of genetic polymorphism detection devices to predict drug response and toxicity using nucleic acid-chromatography strip   [from FY2013]

At present, it has become clear that part of the response to drugs, such as drug efficacy and side effects, is greatly influenced by single-nucleotide polymorphisms (SNPs) in genes such as those for drug-metabolizing enzymes and drug transporters. Therefore, we aimed to construct a device (nucleic acid chromatography strip) that would allow for convenient and quick detection of drug reactivity gene SNPs in patients at their bedside or point of care. In the present study, we targeted mitochondrial 1555A>G, which causes the onset of hearing loss induced by aminoglycoside antibiotics, as a model for drug reactivity SNPs. We used allele-specific primers with DNA tags and biotin labels and amplified the DNA by PCR. The PCR product was mixed with developing solution containing avidin-labeled blue nanoparticles and developed on a strip on which DNA oligonucleotides of about 10 bases, with sequences complementary to the DNA tags, are bound in a line. After a few minutes, the genotype can be detected—using a single strip—by noting the position on which a blue line is detected on the strip. Using this method, it is possible to determine the genotype of a patient easily and within approximately two hours from taking blood samples.

Yoichi Haga, Graduate School of Biomedical Engineering
Wearable blood pressure sensor using ultrasonic array sheet   [from FY2013]

A blood pressure measurement system using ultrasonic array sheet has been developed. An ultrasound waves are transmitted from PMN-PT piezo-electric array fabricated by MEMS technique. The diameter change of blood vessel can be obtained by detecting the ultrasound echo signals. An ultrasonic array sheet and a detecting system were fabricated and evaluated. Using the fabricated sensors and detecting system, the diameter change of the radial artery was able to be measured. The measured diameter change closely corresponds to conventional blood pressure measurements and electrocardiograms.

Yu-Ching LIN, WPI Advanced Institute for Materials Research
Miniaturized wide-field MEMS scanner for OCT observation and laser therapy in endoscopic probe
[from FY2013 to FY2014]

Knowledge based Medical Device Cluster / Miyagi Area ICR

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